Here are all the settings for Worldspan, for Windows XP, 7 8 and 10.
Internet Explorer > Internet Options > Content > click on clear ssl state.
Internet Explorer > Internet Options > General > click on delete browser cache and delete a few things there.
Internet Explorer > Internet Options > Security > Trusted Sites > Custom Level > here enable “download active x” (there are two options).
Internet Explorer > Internet Options > Privacy > empty box for “Turn on Pop-up Blocker”.
Internet Explorer > Internet Options > Advanced > disable SSL 3 box, enable to TLS if it’s not enabled.
Internet Explorer > Tools > Compatibility View Settings > add these three websites: travelport.com / worldspan.com / wspan.com.
Usually, for Windows 10 for example, you only need to enable download active x from IE options, trusted sites, custom level. And it will work with no problems.
For older windows like Windows XP, do all the steps you see in the article here.
For Windows 10, be sure to use Internet Explorer and Not Edge. Type in the search bar “Internet Explorer” to launch it.